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Recombinant Human EPO protein (NP_000790.2) is produced in Sia-Adjusted Human Cell Line. This expression system is used for the production of glycoproteins and antibodies with different sialylation degrees.
This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood.