Recombinant Human F9 Protein, Sia-Adjusted Human Cell Lines (CAT#: GLJF-0722-JF878)

Product Overview	Recombinant Human F9 protein (NP_000124.1) is produced in Sia-Adjusted Human Cell Lines. This expression system is used for the production of glycoproteins and antibodies with different sialylation degree.
Source	Sia-Adjusted Human Cell Lines
Species	Human
Tag	His-tag, FC-tag
Purity	>90%, determined by SDS-PAGE.
Endotoxin Level	Regular batch
Conjugation	None

Target	F9
Full Name	Coagulation factor IX
Gene ID	2158
Uniprot ID	P00740
Accession Number	NP_000124.1
Background	This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.
Alternate Names	Coagulation Factor IX; Plasma Thromboplastic Component; Plasma Thromboplastin Component; Christmas Factor; EC 3.4.21.22; PTC; Christmas Disease; Hemophilia B; Factor IX F9; Factor IX; EC 3.4.21; Factor 9; F9 P22; THPH8; HEMB; FIX; P19