GlycoErase™ ADRB2 Knockout Glycoengineered Cell

GlycoErase™ ADRB2 knockout glycoengineered cell targets the beta-2 adrenergic receptor, a G protein-coupled receptor that regulates Ca(V)1.2 channel signaling and transcription of alpha-synuclein. Loss of ADRB2 function enables investigation of GPCR signaling, calcium dynamics, and disease links including Parkinson's, asthma, obesity, diabetes, and cardiovascular disorders. This model is valuable for studying receptor signaling, neurobiology, and therapeutic discovery.

KO Cell Lines

As requested by the client.

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

ADRB2

Adrenoceptor Beta 2

BAR; ARB2; B2AR; ADRBR; ADRB2R; BETA2AR

5q32

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease.