GlycoErase™ ADRB2 Knockout HepG2 Cell Line

GlycoErase™ ADRB2 knockout HepG2 cell line eliminates ADRB2 expression in HepG2 cells. The beta-2-adrenergic receptor (ADRB2) is a GPCR that regulates calcium signaling, adenylyl cyclase activation, and cAMP-dependent kinase pathways. It also influences transcription of alpha-synuclein and is implicated in respiratory, cardiovascular, metabolic, and neurodegenerative disorders. This knockout supports studies of GPCR signaling, adrenergic pathway modulation, and receptor pharmacology in a hepatic context, with applications in drug discovery, metabolic research, and neurobiology.

KO Cell Lines

Human

Epithelial-like, adherent

1:4~1:6

HepG2

Hepatoblastoma

Liver

Hepatoblastoma

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

DMEM & FBS & Glutamine

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

ADRB2

Adrenoceptor Beta 2

BAR; ARB2; B2AR; ADRBR; ADRB2R; BETA2AR

5q32

This gene encodes the beta-2-adrenergic receptor, a G protein-coupled receptor directly linked to the class C L-type calcium channel Ca(V)1.2. The receptor forms a complex with a G protein, adenylyl cyclase, cAMP-dependent kinase, and phosphatase PP2A, enabling rapid and specific signal transmission. It also regulates alpha-synuclein transcription, with both genes linked to Parkinson's disease risk. This intronless gene shows variations and expression changes associated with nocturnal asthma, obesity, type 2 diabetes, and cardiovascular disease.