GlycoErase™ ADRB2 Knockout CHO-K1 Cell Line

GlycoErase™ ADRB2 knockout CHO-K1 cell line is a Chinese hamster ovary (CHO-K1) model in which ADRB2 expression has been eliminated. The beta-2-adrenergic receptor (ADRB2) is a G protein-coupled receptor that regulates rapid signal transduction via its association with calcium channels, adenylyl cyclase, and cAMP-dependent kinases. It also functions as a transcriptional regulator of alpha-synuclein and has been implicated in respiratory, metabolic, cardiovascular, and neurodegenerative disorders. The knockout of ADRB2 in the CHO-K1 background provides a specialized system for studying GPCR signaling, adrenergic pathway modulation, and receptor-channel interactions, while supporting applications in drug discovery, receptor pharmacology, metabolic disease research, and neurobiology.

KO Cell Lines

Hamster

Epithelial, adherent

1:3~1:5

CHO-K1

Chinese hamster ovary

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

FBS & Penicillin/Streptomycin & Proline & RPMI

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

ADRB2

Adrenoceptor Beta 2

BAR; ARB2; B2AR; ADRBR; ADRB2R; BETA2AR

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease.