GlycoFlux™ Human ADRB2 Overexpression HEK293T Cell Line (CAT#: GLJF-0925-JF491)

Description	GlycoFlux™ human ADRB2 overexpression HEK293T cell line is a stable cell line overexpressing ADRB2, a β2-adrenergic receptor that couples to L-type calcium channels and G-protein complexes to mediate rapid cAMP signaling. ADRB2 regulates α-synuclein transcription and is linked to diseases including Parkinson's, asthma, obesity, diabetes, and cardiovascular dysfunction. This system is ideal for GPCR pharmacology, neurodegeneration research, and cardiometabolic drug discovery.
Product Type	Overexpression Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293T
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	qPCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Penicillin/Streptomycin
Application	Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	ADRB2
Full Name	Adrenoceptor Beta 2
Alternative Name	BAR; ARB2; B2AR; ADRBR; ADRB2R; BETA2AR
Location	5q32
Gene ID	154
Summary	The beta-2 adrenergic receptor is a G protein-coupled receptor (GPCR) that interacts with the L-type calcium channel Ca(V)1.2. This receptor complex includes G proteins, adenylyl cyclase, and phosphatase PP2A, enabling rapid signaling. It regulates alpha-synuclein transcription, which is linked to Parkinson's disease, asthma, obesity, type 2 diabetes, and cardiovascular disease.