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GlycoFlux™ Human ADRB2 Overexpression HEK293T Cell Line

CAT#: GLJF-0925-JF491

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human ADRB2 overexpression HEK293T cell line is a stable cell line overexpressing ADRB2, a β2-adrenergic receptor that couples to L-type calcium channels and G-protein complexes to mediate rapid cAMP signaling. ADRB2 regulates α-synuclein transcription and is linked to diseases including Parkinson's, asthma, obesity, diabetes, and cardiovascular dysfunction. This system is ideal for GPCR pharmacology, neurodegeneration research, and cardiometabolic drug discovery.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
HEK293T
Lineage
Embryonic kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Penicillin/Streptomycin
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
ADRB2
Full Name
Adrenoceptor Beta 2
Alternative Name
BAR; ARB2; B2AR; ADRBR; ADRB2R; BETA2AR
Location
5q32
Gene ID
154
Summary
The beta-2 adrenergic receptor is a G protein-coupled receptor (GPCR) that interacts with the L-type calcium channel Ca(V)1.2. This receptor complex includes G proteins, adenylyl cyclase, and phosphatase PP2A, enabling rapid signaling. It regulates alpha-synuclein transcription, which is linked to Parkinson's disease, asthma, obesity, type 2 diabetes, and cardiovascular disease.
For Research Use Only.
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