GlycoErase™ G6PC2 Knockout HEK293T Cell Line (CAT#: GLJF-0825-JF510)

Description	GlycoErase™ G6PC2 knockout HEK293T cell line is a human HEK293T model lacking G6PC2 expression. G6PC2 is expressed in pancreatic islets and, while catalytically inactive, is an important autoantigen in type 1 diabetes. Disruption in HEK293T cells enables mechanistic exploration of islet-related glucose sensing, autoimmune recognition, and antigen presentation, supporting translational diabetes research and therapeutic screening.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293T
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Penicillin/Streptomycin
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	G6PC2
Full Name	Glucose-6-Phosphatase Catalytic Subunit 2
Alternative Name	IGRP
Location	2q31.1
Gene ID	57818
Summary	This glucose-6-phosphatase family member is expressed in pancreatic islets, lacks enzymatic phosphohydrolase activity, and is a target in autoimmune diabetes. Several transcript variants are known.