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GlycoErase™ G6PC2 Knockout HepG2 Cell Line

CAT#: GLJF-0825-JF626

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ G6PC2 knockout HepG2 cell line eliminates G6PC2, a glucose-6-phosphatase family member predominantly expressed in pancreatic islets. Unlike other isoforms, G6PC2 lacks catalytic activity but is a known autoimmune target in diabetes. This knockout supports research on autoimmune diabetes, islet biology, and glucose regulation, with applications in therapeutic development for diabetes and pancreatic hormone regulation.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
G6PC2
Full Name
Glucose-6-Phosphatase Catalytic Subunit 2
Alternative Name
IGRP
Location
2q31.1
Gene ID
57818
Summary
This glucose-6-phosphatase family member, expressed in pancreatic islets, lacks catalytic activity and is targeted by autoimmune responses in diabetes. Multiple splice variants are documented.
For Research Use Only.
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