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GlycoErase™ GALNT10 Knockout IST-Mes2 Cell Line

CAT#: GLJF-0425-JF924

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Overview Specification Target Information Related Products
Overview
Description
The GALNT10 knockout IST-Mes2 cell line lacks GALNT10 protein, polypeptide N-acetylgalactosaminyltransferase 10, involved in O-linked glycosylation and Notch signaling. GALNT10 knockout in IST-Mes2 cells can dissect O-glycosylation's role in Pleural Mesothelioma Notch signaling, potentially impacting Notch-mediated cell fate decisions, tumor growth, and microenvironment interactions influenced by Notch.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:8
Cell Line
IST-Mes2
Primary Disease
Pleural mesothelioma
Lineage
Pleura
Lineage Subtype
Pleural mesothelioma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
GALNT10
Full Name
Polypeptide N-acetylgalactosaminyltransferase 10
Alternative Name
GalNAc-T10
Location
5q33.2
Gene ID
55568
Summary
Catalyzes the first step in mucin-type oligosaccharide synthesis by transferring GalNAc from UDP-GalNAc to polypeptide acceptors.
For Research Use Only.
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