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GlycoErase™ LDHD Knockout Jurkat Cell Line

CAT#: GLJF-0825-JF767

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ LDHD knockout Jurkat cell line is a Jurkat T cell model without LDHD expression. LDHD encodes a D-isomer-specific 2-hydroxyacid dehydrogenase with activities including D-lactate and D-glycerate dehydrogenase. Mutations alter stereospecific metabolic processing. This knockout line enables the study of rare metabolic pathways, stereospecific metabolism, and mitochondrial energy regulation in immune responses.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Suspension-growing
Passage Ratio
1:3~1:5
Cell Line
Jurkat cell line
Primary Disease
T-cell acute lymphoblastic leukemia (T-ALL)
Lineage
T Lymphocyte
Lineage Subtype
T-cell acute lymphoblastic leukemia (T-ALL)
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & RPMI
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
LDHD
Full Name
Lactate Dehydrogenase D
Alternative Name
DLD; DLACD
Location
16q23.1
Gene ID
197257
Summary
The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.
For Research Use Only.
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