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GlycoErase™ OGT Knockout Jurkat Cell Line

CAT#: GLJF-0425-JF1221

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Overview Specification Target Information Related Products
Overview
Description
OGT knockout Jurkat cell line lacks OGT protein, O-linked N-acetylglucosamine (GlcNAc) transferase, adding O-GlcNAc to proteins and regulating phosphorylation. OGT knockout in Jurkat cells enables study of O-GlcNAc modification disruption in T-cell leukemia, potentially broadly impacting protein glycosylation, phosphorylation balance, and O-GlcNAc/phosphorylation-regulated tumor processes in T-ALL.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Suspension-growing
Passage Ratio
1:3~1:5
Cell Line
Jurkat cell line
Primary Disease
T-cell acute lymphoblastic leukemia (T-ALL)
Lineage
T Lymphocyte
Lineage Subtype
T-cell acute lymphoblastic leukemia (T-ALL)
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & RPMI
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
OGT
Full Name
O-linked N-acetylglucosamine (GlcNAc) transferase
Alternative Name
O-GLCNAC, MGC22921, FLJ23071, HRNT1, OGT1
Location
Xq13.1
Gene ID
8473
Summary
Catalyzes the addition of N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues, potentially competing with phosphorylation.
For Research Use Only.
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