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GlycoErase™ PGM1 Knockout HEK293 Cell Line

CAT#: GLJF-0825-JF432

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ PGM1 knockout HEK293 cell line is a HEK293 model without PGM1 expression. PGM1 encodes phosphoglucomutase 1, catalyzing the conversion of glucose-1-phosphate and glucose-6-phosphate, critical for glycogen and glucose metabolism. Mutations lead to glycogen storage disease type 14. This knockout provides a human system for studying carbohydrate metabolism, inherited glycogen disorders, and therapeutic strategies for metabolic syndromes.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
HEK293
Lineage
Embryonic kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & Proline & RPMI
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
PGM1
Full Name
Phosphoglucomutase 1
Alternative Name
CDG1T; GSD14
Location
1p31.3
Gene ID
5236
Summary
This gene encodes phosphoglucomutase (PGM), which catalyzes the interconversion of glucose-1-phosphate and glucose-6-phosphate. Mutations in this gene cause glycogen storage disease type 14. Several transcript variants encoding different isoforms have been identified.
For Research Use Only.
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