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GlycoErase™ PRKAA1 Knockout HepG2 Cell Line

CAT#: GLJF-0825-JF702

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ PRKAA1 knockout HepG2 cell line is a HepG2 model lacking PRKAA1, the α1 catalytic subunit of AMPK, which senses cellular energy via AMP/ATP changes and regulates metabolic pathways. This knockout facilitates studies of energy-stress signaling, metabolic rewiring, and AMPK-dependent pathway pharmacology in liver metabolism.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
PRKAA1
Full Name
Protein Kinase Amp-Activated Catalytic Subunit Alpha 1
Alternative Name
AMPK; AMPKa1; AMPK alpha 1
Location
5p13.1
Gene ID
5562
Summary
The encoded protein is the alpha catalytic chain of AMP-activated protein kinase (AMPK), which responds to increased AMP/ATP ratios by phosphorylating metabolic enzymes to conserve energy. Several isoforms arise from alternative transcripts.
For Research Use Only.
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