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Recombinant Human CRLF1 protein (NP_004741.1) is produced in Sia-Adjusted Human Cell Lines. This expression system is used for the production of glycoproteins and antibodies with different sialylation degree.
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome.