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Recombinant Human ESM1 protein (NP_001129076.1) is produced in Sia-Increased Human Cell Line. This expression system is used for the production of glycoproteins with high sialylation with fucosylation.
This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene.