GlycoErase™ ALDOC Knockout HEK293T Cell Line

GlycoErase™ ALDOC knockout HEK293T cell line is a HEK293T model in which ALDOC expression has been eliminated. ALDOC is a glycolytic enzyme that catalyzes the aldol cleavage of fructose-1,6-bisphosphate and fructose-1-phosphate, and it is expressed predominantly in the hippocampus and Purkinje cells of the brain. Removal of ALDOC in the HEK293T background creates a model to investigate glycolytic regulation, neuronal metabolic pathways, and the role of energy metabolism in neurodegeneration, supporting applications in neuroscience, brain metabolism research, and glycolysis-focused drug discovery.

KO Cell Lines

Human

Epithelial-like, adherent

1:2~1:4

HEK293T

Embryonic kidney

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

DMEM & FBS & Penicillin/Streptomycin

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

ALDOC

Aldolase, Fructose-Bisphosphate C

ALDC

17q11.2

The brain-specific form of fructose-bisphosphate aldolase, found in the hippocampus and Purkinje cells, catalyzes the reversible breakdown of fructose-1,6-bisphosphate and fructose 1-phosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate or glyceraldehyde.