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GlycoErase™ ALDOC Knockout HepG2 Cell Line

CAT#: GLJF-0825-JF611

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ ALDOC knockout HepG2 cell line eliminates ALDOC, a glycolytic enzyme that cleaves fructose-1,6-bisphosphate and fructose-1-phosphate, normally enriched in neuronal tissues such as hippocampus and Purkinje cells. In a hepatic background, its removal provides a tool to study glycolytic regulation, metabolic plasticity, and energy metabolism pathways, supporting applications in cancer research, metabolic disorder modeling, and glycolysis-focused drug discovery.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
ALDOC
Full Name
Aldolase, Fructose-Bisphosphate C
Alternative Name
ALDC
Location
17q11.2
Gene ID
230
Summary
This gene encodes a class I fructose-bisphosphate aldolase expressed in the hippocampus and Purkinje cells. It catalyzes the reversible cleavage of fructose-1,6-bisphosphate and fructose-1-phosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate or glyceraldehyde, respectively.
For Research Use Only.
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