GlycoErase™ EPM2A Knockout HepG2 Cell Line (CAT#: GLJF-0825-JF623)

Description	GlycoErase™ EPM2A knockout HepG2 cell line eliminates EPM2A, a dual-specificity phosphatase that prevents glycogen hyperphosphorylation and insoluble aggregate formation. Mutations cause Lafora disease, a fatal neurodegenerative disorder characterized by glycogen inclusions. This knockout provides a system to study glycogen regulation, Lafora body formation, and neurodegenerative disease mechanisms, supporting research in glycogen metabolism and rare disease biology.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:4~1:6
Cell Line	HepG2
Primary Disease	Hepatoblastoma
Lineage	Liver
Lineage Subtype	Hepatoblastoma

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Glutamine
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	EPM2A
Full Name	Epm2A Glucan Phosphatase, Laforin
Alternative Name	EPM2; MELF; MELF2
Location	6q24.3
Gene ID	7957
Summary	The protein encoded here is a dual-specificity phosphatase that prevents excess glycogen phosphorylation, avoiding insoluble aggregate buildup. Mutations cause Lafora disease, a fatal epilepsy with Lafora body deposits.