GlycoErase™ GSK3A Knockout HEK293 Cell Line (CAT#: GLJF-0825-JF404)

Description	GlycoErase™ GSK3A knockout HEK293 cell line is a HEK293 model with GSK3A expression removed. GSK3A encodes a multifunctional Ser/Thr kinase that regulates glycogen synthase, JUN, and multiple signaling pathways including WNT and PI3K. It is also implicated in the production of beta-amyloid peptides relevant to Alzheimer's disease. This knockout system provides a human-based platform for investigating kinase signaling, glycogen regulation, and neurodegenerative disease pathways, supporting translational research in oncology, metabolism, and neurological therapeutics.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & Proline & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	GSK3A
Full Name	Glycogen Synthase Kinase 3 Alpha
Location	19q13.2
Gene ID	2931
Summary	This gene encodes a multifunctional Ser/Thr protein kinase involved in regulating proteins like glycogen synthase and transcription factors. It plays a role in WNT and PI3K pathways and controls beta-amyloid production, linked to Alzheimer's disease.