Close
0
Inquiry Basket

There is no product in the shopping cart, buy it!

Hot Products
Monosaccharide Products
Oligosaccharide Products
Polysaccharide Products
Carbohydrate-based Surfactant Products
Blood Group Antigen Products
Glycoprotein Products
Glycopeptide Products
Nucleotide Sugar Products
Glycoprotein Assay Kits
Comprehensive Glycoprotein Reagents
Glycoengineered Cell Products
Glycoengineering Viral Particle Products
Glycolipid Products

GlycoErase™ HK2 Knockout HepG2 Cell Line

CAT#: GLJF-0825-JF643

Datasheet Request COA
Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ HK2 knockout HepG2 cell line eliminates HK2, the insulin-responsive, mitochondria-associated hexokinase isoform highly expressed in tumors to drive aerobic glycolysis. This knockout provides a model to study hepatic insulin signaling, tumor metabolism, and energy regulation, supporting applications in oncology and metabolic drug discovery.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
HK2
Full Name
Hexokinase 2
Alternative Name
HKII; HXK2
Location
2p12
Gene ID
3099
Summary
Hexokinase 2 is the main skeletal muscle isoform responsible for phosphorylating glucose to form glucose-6-phosphate, the initial step in most glucose metabolic pathways. It associates with the outer mitochondrial membrane and its expression responds to insulin levels. Studies in rats indicate its involvement in elevated glycolytic rates in rapidly proliferating cancer cells.
For Research Use Only.
Online Inquiry
Copyright © Creative Biolabs. All Rights Reserved.