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Recombinant Human ATP binding cassette subfamily B member 1 (ABCB1) (236-297 aa) [His-Tag], E. coli

CAT#: GP02-001J

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Specifications Target Information Related Products
Specifications
Product Overview
Recombinant Human ATP binding cassette subfamily B member 1 (NP_000918.2) (236-297 aa) was expressed in E. coli with a 6xHis-tag at the N-terminus. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, IP.
Source
E. coli
Species
Human
Fragment
236-297 aa
Sequence
LSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANI
Tag
6xHis-tag at the N-terminus
Predicted MW
10.8 kDa
Purity
>95%, determined by SDS-PAGE.
Conjugation
Unconjugated
Target Information
Target
ABCB1
Full Name
ATP binding cassette subfamily B member 1
Gene ID
5243
Uniprot ID
P08183
Accession Number
NP_000918.2
Background
The protein is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs.
Alternate Names
CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; p-170
For Research Use Only.
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