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Recombinant Human C8A protein (NP_000553.1) is produced in Sia-Increased Human Cell Lines. This expression system is used for the production of glycoproteins with high sialylation and core fucosylation.
C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency.