GlycoErase™ ALDOC Knockout HEK293 Cell Line

GlycoErase™ ALDOC knockout HEK293 cell line is a human embryonic kidney (HEK293) model in which ALDOC expression has been eliminated. ALDOC is a glycolytic enzyme that catalyzes the aldol cleavage of fructose-1,6-bisphosphate and fructose-1-phosphate, and it is expressed predominantly in neuronal tissues such as the hippocampus and Purkinje cells. Removal of ALDOC in the HEK293 background creates a versatile model to investigate glycolytic regulation, neuron-associated energy pathways, and cross-talk between metabolism and brain-related functions, supporting applications in neurobiology, metabolic disorder studies, and glycolysis-focused drug screening.

KO Cell Lines

Human

Epithelial-like, adherent

1:2~1:4

HEK293

Embryonic kidney

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

FBS & Penicillin/Streptomycin & Proline & RPMI

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

ALDOC

Aldolase, Fructose-Bisphosphate C

ALDC

17q11.2

This brain-specific class I fructose-bisphosphate aldolase, expressed in hippocampus and Purkinje cells, catalyzes reversible cleavage of fructose-1,6-bisphosphate and fructose 1-phosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate or glyceraldehyde.