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GlycoFlux™ Human PPP1R3A Overexpression Raji Cell Line

CAT#: GLJF-0925-JF972

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human PPP1R3A overexpression Raji cell line is a stable cell line engineered to overexpress PPP1R3A, the muscle glycogen-targeting regulatory subunit that binds PP1c with high affinity to enhance dephosphorylation of glycogen-bound substrates such as glycogen synthase and phosphorylase kinase. This model allows direct interrogation of PP1 targeting to glycogen and control of glycogen synthesis/breakdown.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Lymphoblast-like, suspension growth
Passage Ratio
1:2~1:4
Cell Line
Raji
Primary Disease
Burkitt's lymphoma
Lineage
B lymphocyte (B cell)
Lineage Subtype
Mature B cell, widely used in EBV-related studies
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
FBS & RPMI
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
PPP1R3A
Full Name
Protein Phosphatase 1 Regulatory Subunit 3A
Alternative Name
GM; PP1G; PPP1R3
Location
7q31.1
Gene ID
5506
Summary
The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase.
For Research Use Only.
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