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GlycoFlux™ MMLV-Human PTGER4 Viral Particle (CAT#: GLJF-1025-JF502)

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Description GlycoFlux™ MMLV-PTGER4 Viral Particle delivers PTGER4 (EP4), a PGE₂ GPCR that drives TCF signaling, EGR1 induction, COX-2 mRNA control, and GSK3 phosphorylation; this construct establishes stable mammalian expression lines for prostaglandin biology and immunomodulation.
Product Type Recombinant MMLV Retrovirus
Target PTGER4
Species Human
Promotor MMLV 5' LTR promoter
Packaging System Retrovirus
Packaging Cell HEK293T
Application This MMLV vector is a common retroviral vector system that permanently integrates a gene into the host cell's genome, allowing for long-term, sustained expression. It is a popular tool for gene manipulation in dividing cells and for generating iPS cells in biomedical research.
Shipping Shipped on dry ice with temperature held at or below -80°C.
Storage Store at -80°C to maintain their titer and stability.
Handling Notes Store products at -80°C, and avoid repeated freeze-thaw cycles to maintain viral titer. For safety, always handle the products in a biological safety cabinet, using appropriate personal protective equipment like lab coats, gloves, and eye protection.
Product Disclaimer These products are for research use only and not for diagnostic or clinical use. The user assumes full responsibility for all safety protocols and compliance with relevant regulations. While we are committed to quality, Creative Biolabs makes no guarantee as to the performance of these products in a specific application.
Titer Assay qPCR
Mycoplasma Test Negative
Sterility Sterility testing confirmed no microbial contamination.
Transduction Evaluation On request, Creative Biolabs conducts in vitro or in vivo transduction assays to evaluate lentiviral delivery to target cells and to quantify transgene expression and function.
Insert Identity Confirmation Creative Biolabs verifies all retroviral vectors by a PCR-based proviral integration check. In brief, cells are transduced with serial dilutions of the retroviral preparation and, after several days, genomic DNA is extracted. A predefined segment of the expected retroviral insert is then amplified by PCR to confirm correct identity and integration.
Full Name Prostaglandin E Receptor 4
Alternative Name EP4; EP4R
Location 5p13.1
Gene ID 5734
Summary This gene encodes a G-protein coupled receptor that is one of four receptors for prostaglandin E2 (PGE2). It triggers T-cell factor signaling, drives PGE2-mediated EGR1 expression, influences cyclooxygenase-2 mRNA turnover, and induces phosphorylation of glycogen synthase kinase-3. Mouse knockout models indicate roles in newborn cardiovascular adjustment, bone density regulation, and initiation of cutaneous immune defense.
For Research Use Only.
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