Recombinant Human COL1A1 Protein, Sia-Adjusted Human Cell Lines

Recombinant Human COL1A1 protein (NP_000079.2) is produced in Sia-Adjusted Human Cell Lines. This expression system is used for the production of glycoproteins and antibodies with different sialylation degree.

Sia-Adjusted Human Cell Lines

Human

His-tag, FC-tag

>90%, determined by SDS-PAGE.

Regular batch

None

COL1A1

Collagen alpha-1 (I) chain

This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Collagen, Type I, Alpha 1; Alpha-1 Type I Collagen; Collagen Of Skin, Tendon And Bone, Alpha-1 Chain; Collagen Alpha-1(I) Chain Preproprotein; Type I Procollagen Alpha 1 Chain; Collagen Alpha 1 Chain Type I; Pro-Alpha-1 Collagen Type 1; Alpha1(I) Procollagen; Type I Proalpha 1; EDSC; OI4; OI1; OI2; OI3