Recombinant Human CST6 Protein, Glycoengineered Pichia pastoris

Recombinant Human CST6 protein (NP_001314.1) is produced in Glycoengineered Pichia pastoris. This expression system is used for the production of glycoproteins and antibodies with human post-translational modifications.

Glycoengineered Pichia pastoris

Human

His-tag, FC-tag

>90%, determined by SDS-PAGE.

Regular batch

None

CST6

Cystatin-M

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.

Cystatin E/M; Cystatin-6; Cystatin-E; Cysteine Proteinase Inhibitor; Cystatin M/E; Cystatin 6; Cystatin M