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Recombinant Human FREM1 protein (NP_001171175.1) is produced in Sia-Adjusted Human Cell Line. This expression system is used for the production of glycoproteins and antibodies with different sialylation degrees.
This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described.