GlycoErase™ FBP1 Knockout HEK293 Cell Line (CAT#: GLJF-0825-JF392)

Description	GlycoErase™ FBP1 knockout HEK293 cell line is a human embryonic kidney (HEK293) model lacking FBP1 expression. FBP1 encodes fructose-1,6-bisphosphatase, a key enzyme in gluconeogenesis that catalyzes the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate. Deficiency of FBP1 is associated with hypoglycemia and metabolic acidosis. The knockout of FBP1 in the HEK293 background provides a functional system to study gluconeogenesis, energy homeostasis, and metabolic disease, supporting applications in glucose metabolism research, rare metabolic disorder modeling, and therapeutic development.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & Proline & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	FBP1
Full Name	Fructose-Bisphosphatase 1
Alternative Name	FBP
Location	9q22.32
Gene ID	2203
Summary	Fructose-1,6-bisphosphatase 1 is a gluconeogenesis enzyme that hydrolyzes fructose-1,6-bisphosphate into fructose 6-phosphate and inorganic phosphate. Deficiency results in hypoglycemia and metabolic acidosis.