GlycoFlux™ Human FBP1 Overexpression Jurkat Cell Line

GlycoFlux™ human FBP1 overexpression Jurkat cell line is a stable cell line engineered to express fructose-1,6-bisphosphatase 1 (FBP1), a critical gluconeogenic enzyme that hydrolyzes fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate. Deficiency of FBP1 leads to hypoglycemia and metabolic acidosis, underscoring its central role in glucose balance. This model provides a robust platform to study T-cell metabolic regulation, the interplay of gluconeogenesis with immune responses, and mechanisms of metabolic disorders involving impaired glucose production.

Overexpression Cell Lines

Human

Suspension-growing

1:3~1:5

Jurkat cell line

T-cell acute lymphoblastic leukemia (T-ALL)

T Lymphocyte

T-cell acute lymphoblastic leukemia (T-ALL)

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

qPCR, Sanger Sequencing

FBS & Penicillin/Streptomycin & RPMI

Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

FBP1

Fructose-Bisphosphatase 1

FBP

9q22.32

Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.