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GlycoErase™ FBP1 Knockout HEK293T Cell Line

CAT#: GLJF-0825-JF508

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ FBP1 knockout HEK293T cell line is a human embryonic kidney (HEK293T) model lacking FBP1 expression. FBP1 encodes fructose-1,6-bisphosphatase, a rate-setting gluconeogenic enzyme that converts fructose-1,6-bisphosphate to fructose-6-phosphate and shapes redox balance. Deletion in HEK293T cells provides a human platform to study gluconeogenic control points, metabolic plasticity under hypoxia or growth factor signaling, and disease mechanisms linked to hypoglycemia and acidosis.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
HEK293T
Lineage
Embryonic kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Penicillin/Streptomycin
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
FBP1
Full Name
Fructose-Bisphosphatase 1
Alternative Name
FBP
Location
9q22.32
Gene ID
2203
Summary
Fructose-1,6-bisphosphatase 1 is a regulatory enzyme in gluconeogenesis, catalyzing the conversion of fructose-1,6-bisphosphate into fructose 6-phosphate and phosphate. Deficiency leads to hypoglycemia and metabolic acidosis.
For Research Use Only.
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