GlycoErase™ PPP1R42 Knockout Jurkat Cell Line (CAT#: GLJF-0825-JF811)

Description	GlycoErase™ PPP1R42 knockout Jurkat cell line is a Jurkat model in which PPP1R42 expression has been eliminated. PPP1R42 interacts with γ-tubulin and protein phosphatase 1 (PP1) to positively regulate PP1 activity and maintain centrosome integrity during separation. This knockout provides a focused system to investigate centrosome biology, mitotic fidelity, and PP1-mediated control of cell division, supporting applications in cell cycle research and oncology.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Suspension-growing
Passage Ratio	1:3~1:5
Cell Line	Jurkat cell line
Primary Disease	T-cell acute lymphoblastic leukemia (T-ALL)
Lineage	T Lymphocyte
Lineage Subtype	T-cell acute lymphoblastic leukemia (T-ALL)

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	PPP1R42
Full Name	Protein Phosphatase 1 Regulatory Subunit 42
Alternative Name	dtr; TLLR; TLRR; LRRC67
Location	8q13.1
Gene ID	286187
Summary	The protein encoded by this gene can interact with gamma-tubulin and PP1 phosphatase, a regulator of centrosome separation. The encoded protein is a positive regulator of PP1 phosphatase and thus plays a role in the control of centrosome integrity.