GlycoErase™ PRDM8 Knockout HEK293 Cell Line (CAT#: GLJF-0825-JF469)

Description	GlycoErase™ PRDM8 knockout HEK293 cell line is a HEK293 model lacking PRDM8, a SET-domain histone methyltransferase that represses transcription and interacts with laforin/malin complexes linked to glycogen regulation. This knockout supports epigenetic mechanism research, human neuronal pathway modeling, and studies of chromatin-metabolism cross-talk with relevance to neurodegeneration and metabolic disorders.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & Proline & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	PRDM8
Full Name	Pr/Set Domain 8
Alternative Name	PFM5; EPM10; KMT8D
Location	4q21.21
Gene ID	56978
Summary	This gene encodes a histone methyltransferase with SET and zinc-finger domains that acts mainly as a transcriptional repressor. It interacts with laforin and malin, influencing glycogen metabolism. Alternative transcripts are known.