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GlycoErase™ ST3GAL1 Knockout KD Cell Line

CAT#: GLJF-0425-JF726

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Overview Specification Target Information Related Products
Overview
Description
The ST3GAL1 knockout KD cell line, derived from an extra-cranial rhabdoid tumor, lacks ST3GAL1 protein, ST3 beta-galactoside alpha-2,3-sialyltransferase 1 catalyzing sialylation in Golgi. ST3GAL1 knockout in rhabdoid cancer cells allows investigation of sialylation disruption in this pediatric sarcoma, potentially affecting alpha-2,3-sialylation of glycans, cell surface sialylation, and sialic acid dependent rhabdoid tumor properties.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
KD cell line
Primary Disease
Rhabdoid cancer
Lineage
Soft Tissue
Lineage Subtype
Rhabdoid cancer
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
F-12 & FBS & Penicillin/Streptomycin
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
ST3GAL1
Full Name
ST3 Beta-galactoside alpha-2,3-sialyltransferase 1
Alternative Name
ST3GalA.1, ST3O, SIAT4A, SIATFL
Location
8q24.22
Gene ID
6482
Summary
Catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates; primarily located in the Golgi but can be processed into a soluble form.
For Research Use Only.
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