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GlycoFlux™ Human PDE3A Overexpression HepG2 Cell Line

CAT#: GLJF-0925-JF656

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human PDE3A overexpression HepG2 cell line is a stable cell line engineered to express PDE3A, a cyclic nucleotide phosphodiesterase that hydrolyzes both cAMP and cGMP to regulate signal amplitude and duration. PDE3A controls platelet aggregation and vascular smooth muscle contraction, and inhibitors are explored for heart failure therapy. This system provides a platform for cardiovascular pharmacology, signal transduction, and drug screening.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
PDE3A
Full Name
Phosphodiesterase 3A
Alternative Name
HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A
Location
12p12.2
Gene ID
5139
Summary
The encoded protein is a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase family, which hydrolyzes cAMP and cGMP to control signal duration and strength. It plays a role in platelet aggregation and vascular smooth muscle tone, making it a therapeutic target in heart failure. Multiple isoforms are produced via alternative splicing.
For Research Use Only.
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