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GlycoFlux™ Human PDE3A Overexpression HEK293 Cell Line

CAT#: GLJF-0925-JF424

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human PDE3A overexpression HEK293 cell line elevates PDE3A, a phosphodiesterase that hydrolyzes both cAMP and cGMP to regulate platelet aggregation and vascular smooth muscle tone. This system is relevant for cardiovascular research, heart failure therapeutics, and signal regulation by cyclic nucleotides.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
HEK293
Lineage
Embryonic kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & Proline & DMEM
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
PDE3A
Full Name
Phosphodiesterase 3A
Alternative Name
HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A
Location
12p12.2
Gene ID
5139
Summary
This gene encodes a cyclic nucleotide phosphodiesterase (cGI-PDE) that hydrolyzes both cAMP and cGMP, regulating platelet aggregation and vascular smooth muscle contraction. Inhibitors of this enzyme may treat heart failure. Multiple isoforms exist due to alternative splicing.
For Research Use Only.
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