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GlycoFlux™ Human SIGLEC5 Overexpression HEK293 Cell Line

CAT#: GLJF-0925-JF888

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human SIGLEC5 overexpression HEK293 cell line is a stable human line overexpressing SIGLEC5, a sialic acid-binding receptor that negatively regulates monocytes, macrophages, and neutrophils. As a CD33-related inhibitory receptor, it plays a role in bacterial immune evasion. This platform supports investigation of inhibitory lectin signaling, immune suppression, and pathogen interaction mechanisms.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
HEK293
Lineage
Embryonic kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & Proline & DMEM
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
SIGLEC5
Full Name
Sialic Acid Binding Ig Like Lectin 5
Alternative Name
CD170, OBBP2, CD33L2, OB-BP2, SIGLEC-5, Sialic Acid Binding Ig Like Lectin
Location
19q13.41
Gene ID
8778
Summary
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family, characterized by structural motifs in the immunoglobulin-like domains and sialic acid recognition sites in the first Ig V-set domain. The encoded protein is part of the CD33-related Siglec subgroup and inhibits the activation of monocytes, macrophages, and neutrophils. It also plays a role in immune evasion by Group B Streptococcus (GBS).
For Research Use Only.
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