GlycoErase™ SIGLEC5 Knockout Jurkat Cell Line

GlycoErase™ SIGLEC5 knockout Jurkat cell line is a Jurkat model in which SIGLEC5 expression has been deleted. SIGLEC5 belongs to the CD33-related subset and suppresses activation of monocytes, macrophages, and neutrophils, and also mediates bacterial immune evasion. The knockout Jurkat line offers a platform to investigate innate immune regulation, host-pathogen interactions, and inhibitory signaling, supporting applications in T cell immunology, cytokine profiling, and immunotherapy development.

KO Cell Lines

Human

Suspension-growing

1:3~1:5

Jurkat cell line

T-cell acute lymphoblastic leukemia (T-ALL)

T Lymphocyte

T-cell acute lymphoblastic leukemia (T-ALL)

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

FBS & Penicillin/Streptomycin & RPMI

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

SIGLEC5

Sialic Acid Binding Ig Like Lectin 5

CD170, OBBP2, CD33L2, OB-BP2, SIGLEC-5, Sialic Acid Binding Ig Like Lectin

19q13.41

The gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins feature structural motifs in their immunoglobulin-like domains, along with sialic acid recognition sites in the first Ig V-set domain. The encoded protein belongs to the CD33-related subgroup of Siglecs and inhibits the activation of monocytes, macrophages, and neutrophils. It also contributes to immune evasion by Group B Streptococcus (GBS).