Recombinant Human Atypical chemokine receptor 1 (ACKR1) (1-336 aa) [His-Tag], E. coli

Recombinant Human Atypical chemokine receptor 1 (NP_002027.2) (1-336 aa) was expressed in E. coli with a 10xHis-tag at the N-terminus. The biological activity was determined by its binding ability in a functional ELISA. Immobilized ACKR1 at 3 μg/mL can bind human CCL2, the EC50 of human CCL2 protein is 35 μg/mL. This product can be used in ELISA, WB, IP.

Determined by its binding ability to human CCL2 in a functional ELISA. Immobilized ACKR1 at 3 μg/mL can bind human CCL2, the EC50 of human CCL2 protein is 35 μg/mL.

Human

1-336 aa

MGNCLHRAELSPSTENSSQLDFEDVWNSSYGVNDSFPDGDYGANLEAAAPCHSCNLLDDSALPFFILTSVLGILASSTVLFMLFRPLFRWQLCPGWPVLAQLAVGSALFSIVVPVLAPGLGSTRSSALCSLGYCVWYGSAFAQALLLGCHASLGHRLGAGQVPGLTLGLTVGIWGVAALLTLPVTLASGASGGLCTLIYSTELKALQATHTVACLAIFVLLPLGLFGAKGLKKALGMGPGPWMNILWAWFIFWWPHGVVLGLDFLVRSKLLLLSTCLAQQALDLLLNLAEALAILHCVATPLLLALFCHQATRTLLPSLPLPEGWSSHLDTLGSKS

10xHis-tag at the N-terminus

41.1 kDa

>90%, determined by SDS-PAGE.

Unconjugated

ACKR1

Atypical chemokine receptor 1

This protein is an atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.

FY; Dfy; GPD; DARC; GpFy; CCBP1; CD234; WBCQ1; DARC/ACKR1