Recombinant Marburg virus (strain Kenya/Musoke/1980) Envelope glycoprotein (GP), Yeast (CAT#: GPX-292-Y-J)

Product Overview	Recombinant Marburg virus (strain Kenya/Musoke/1980) Envelope glycoprotein was expressed in Yeast with a His-tag or Tag free. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, and IP.
Biological Activity	Determined by its binding ability in a functional ELISA.
Source	Yeast
Species	Marburg virus (strain Kenya/Musoke/1980)
Tag	His-tag or Tag free
Purity	>90%, determined by SDS-PAGE.
Conjugation	Unconjugated

Target	GP
Full Name	Envelope glycoprotein
Gene ID	920945
Uniprot ID	P35253
Background	GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection).
Alternate Names	GP; Envelope glycoprotein; GP1; GP2