Recombinant Marburg virus (strain Kenya/Musoke/1980) Envelope glycoprotein (GP), Yeast

Recombinant Marburg virus (strain Kenya/Musoke/1980) Envelope glycoprotein was expressed in Yeast with a His-tag or Tag free. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, and IP.

Determined by its binding ability in a functional ELISA.

Yeast

Marburg virus (strain Kenya/Musoke/1980)

His-tag or Tag free

>90%, determined by SDS-PAGE.

Unconjugated

GP

Envelope glycoprotein

GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection).

GP; Envelope glycoprotein; GP1; GP2