GlycoErase™ ADRB2 Knockout HEK293T Cell Line (CAT#: GLJF-0825-JF491)

Description	GlycoErase™ ADRB2 knockout HEK293T cell line is a HEK293T model in which ADRB2 expression has been eliminated. The beta-2-adrenergic receptor (ADRB2) is a G protein-coupled receptor that regulates rapid signal transduction via its association with calcium channels, adenylyl cyclase, and cAMP-dependent kinases. It also functions as a transcriptional regulator of alpha-synuclein and has been implicated in respiratory, metabolic, cardiovascular, and neurodegenerative disorders. The knockout of ADRB2 in the HEK293T background provides a specialized system for studying GPCR signaling, adrenergic pathway modulation, and receptor-channel interactions, while supporting applications in neurobiology, pharmacology, and drug discovery.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293T
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Penicillin/Streptomycin
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	ADRB2
Full Name	Adrenoceptor Beta 2
Alternative Name	BAR; ARB2; B2AR; ADRBR; ADRB2R; BETA2AR
Location	5q32
Gene ID	154
Summary	The beta-2 adrenergic receptor is a G protein-coupled receptor (GPCR) that interacts with the L-type calcium channel Ca(V)1.2. This receptor complex includes G proteins, adenylyl cyclase, and phosphatase PP2A, enabling rapid signaling. It regulates alpha-synuclein transcription, which is linked to Parkinson's disease, asthma, obesity, type 2 diabetes, and cardiovascular disease.