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GlycoErase™ AVPR1A Knockout HepG2 Cell Line

CAT#: GLJF-0825-JF617

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ AVPR1A knockout HepG2 cell line eliminates AVPR1A, a GPCR for arginine vasopressin that mediates phosphatidylinositol-calcium signaling to regulate vascular contraction, platelet aggregation, glycogenolysis, and proliferation. This knockout provides a defined system for GPCR signaling, vasopressin receptor biology, and calcium-dependent hepatic responses, supporting research in cardiovascular biology, platelet function, and therapeutic discovery.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
AVPR1A
Full Name
Arginine Vasopressin Receptor 1A
Alternative Name
V1aR; AVPR1; AVPR V1a
Location
12q14.2
Gene ID
552
Summary
The protein encoded by this gene is a G protein-coupled receptor for arginine vasopressin. Its signaling is mediated by a phosphatidylinositol-calcium pathway, influencing smooth muscle contraction, platelet aggregation, coagulation factor release, and glycogen breakdown.
For Research Use Only.
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