GlycoErase™ AVPR1A Knockout HepG2 Cell Line (CAT#: GLJF-0825-JF617)

Description	GlycoErase™ AVPR1A knockout HepG2 cell line eliminates AVPR1A, a GPCR for arginine vasopressin that mediates phosphatidylinositol-calcium signaling to regulate vascular contraction, platelet aggregation, glycogenolysis, and proliferation. This knockout provides a defined system for GPCR signaling, vasopressin receptor biology, and calcium-dependent hepatic responses, supporting research in cardiovascular biology, platelet function, and therapeutic discovery.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:4~1:6
Cell Line	HepG2
Primary Disease	Hepatoblastoma
Lineage	Liver
Lineage Subtype	Hepatoblastoma

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Glutamine
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	AVPR1A
Full Name	Arginine Vasopressin Receptor 1A
Alternative Name	V1aR; AVPR1; AVPR V1a
Location	12q14.2
Gene ID	552
Summary	The protein encoded by this gene is a G protein-coupled receptor for arginine vasopressin. Its signaling is mediated by a phosphatidylinositol-calcium pathway, influencing smooth muscle contraction, platelet aggregation, coagulation factor release, and glycogen breakdown.