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GlycoErase™ PPP1R7 Knockout Jurkat Cell Line

CAT#: GLJF-0825-JF812

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ PPP1R7 knockout Jurkat cell line is a Jurkat model lacking PPP1R7, a regulatory subunit required for completion of mitosis and for targeting PP1 to mitotic kinetochores. The absence of PPP1R7 enables detailed study of kinetochore phosphatase targeting, chromosome segregation, and spindle checkpoint signaling, and supports applications in anti-mitotic drug discovery and phosphatase pathway analysis.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Suspension-growing
Passage Ratio
1:3~1:5
Cell Line
Jurkat cell line
Primary Disease
T-cell acute lymphoblastic leukemia (T-ALL)
Lineage
T Lymphocyte
Lineage Subtype
T-cell acute lymphoblastic leukemia (T-ALL)
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & RPMI
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
PPP1R7
Full Name
Protein Phosphatase 1 Regulatory Subunit 7
Alternative Name
SDS22
Location
2q37.3
Gene ID
5510
Summary
This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants.
For Research Use Only.
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