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GlycoFlux™ Human EPM2A Overexpression HepG2 Cell Line

CAT#: GLJF-0925-JF623

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human EPM2A overexpression HepG2 cell line is a stable glycoengineered line that constitutively overexpresses laforin (EPM2A), a dual-specificity phosphatase that prevents glycogen hyperphosphorylation. This platform couples glycogen architecture to donor-sugar availability and ER quality control, enabling studies of secretion fidelity, mannose trimming, and glycoprotein aggregation under glycogenic stress.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
EPM2A
Full Name
Epm2A Glucan Phosphatase, Laforin
Alternative Name
EPM2; MELF; MELF2
Location
6q24.3
Gene ID
7957
Summary
The protein encoded here is a dual-specificity phosphatase that prevents excess glycogen phosphorylation, avoiding insoluble aggregate buildup. Mutations cause Lafora disease, a fatal epilepsy with Lafora body deposits.
For Research Use Only.
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