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GlycoFlux™ Human SIGLEC1 Overexpression CHO-K1 Cell Line

CAT#: GLJF-0925-JF839

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human SIGLEC1 overexpression CHO-K1 cell line is a stable glycoengineered line that constitutively overexpresses SIGLEC-1, providing a high-control background for sialoglycan engineering. It is well-suited for affinity/avidity mapping to defined sialylated ligands, evaluation of therapeutic glyco-designs, and virus-binding/trans-enhancement assays in a bioproduction-friendly host.
Product Type
Overexpression Cell Lines
Species
Hamster
Cell Morphology
Epithelial, adherent
Passage Ratio
1:3~1:5
Cell Line
CHO-K1
Lineage
Chinese hamster ovary
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & Proline & DMEM
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
SIGLEC1
Full Name
Sialic Acid Binding Ig Like Lectin 1
Alternative Name
CD169, Sialic acid-binding Ig-like lectin 1, SIGLEC1, sialoadhesin, Sialic Acid Binding Ig Like Lectin
Summary
This gene encodes a protein from the immunoglobulin superfamily, acting as a lectin-like adhesion molecule. The protein binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays a crucial role in several human diseases, bacterial and viral infections, and has been shown to enhance SARS-CoV-2 infection.
For Research Use Only.
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