GlycoFlux™ Human SIGLEC1 Overexpression Jurkat Cell Line

GlycoFlux™ human SIGLEC1 overexpression Jurkat cell line is a stable cell line engineered to express SIGLEC1, a sialic acid-dependent adhesion receptor that binds glycoconjugate ligands and mediates macrophage cell-cell interactions. SIGLEC1 contributes to multiple immune diseases and microbial infections and has been shown to promote SARS-CoV-2 infection. This glycoengineered model provides an effective immune-cell background for studying glycosylation-dependent adhesion, viral immunopathology, and T-cell related cross-talk.

Overexpression Cell Lines

Human

Suspension-growing

1:3~1:5

Jurkat cell line

T-cell acute lymphoblastic leukemia (T-ALL)

T Lymphocyte

T-cell acute lymphoblastic leukemia (T-ALL)

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

qPCR, Sanger Sequencing

FBS & Penicillin/Streptomycin & RPMI

Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

SIGLEC1

Sialic Acid Binding Ig Like Lectin 1

CD169, Sialic acid-binding Ig-like lectin 1, SIGLEC1, sialoadhesin, Sialic Acid Binding Ig Like Lectin

20p13

This gene encodes a protein from the immunoglobulin superfamily, which functions as a lectin-like adhesion molecule. It binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. This type I transmembrane protein is expressed by a subset of macrophages and plays a critical role in mediating cell-cell interactions. The protein is involved in various human diseases and infections, and it has been shown to enhance SARS-CoV-2 infection.