GlycoFlux™ Human SIGLEC1 Overexpression Raji Cell Line (CAT#: GLJF-0925-JF1032)

Description	GlycoFlux™ human SIGLEC1 overexpression Raji cell line is a stable cell line engineered to overexpress SIGLEC1 (CD169), a macrophage-restricted sialic acid-binding lectin that mediates cell-cell interactions. SIGLEC1 has been implicated in multiple human diseases and promotes viral infection, including enhancing SARS-CoV-2 entry. This model supports studies of innate immunity, lectin biology, and pathogen interactions.
Product Type	Overexpression Cell Lines
Species	Human
Cell Morphology	Lymphoblast-like, suspension growth
Passage Ratio	1:2~1:4
Cell Line	Raji
Primary Disease	Burkitt's lymphoma
Lineage	B lymphocyte (B cell)
Lineage Subtype	Mature B cell, widely used in EBV-related studies

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	qPCR, Sanger Sequencing
Culture Medium	FBS & RPMI
Application	Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SIGLEC1
Full Name	Sialic Acid Binding Ig Like Lectin 1
Alternative Name	CD169; Sialic acid-binding Ig-like lectin 1; SIGLEC1; sialoadhesin; Sialic Acid Binding Ig Like Lectin
Location	20p13
Gene ID	6614
Summary	This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection.