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GlycoFlux™ Human SIGLEC1 Overexpression Raji Cell Line

CAT#: GLJF-0925-JF1032

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human SIGLEC1 overexpression Raji cell line is a stable cell line engineered to overexpress SIGLEC1 (CD169), a macrophage-restricted sialic acid-binding lectin that mediates cell-cell interactions. SIGLEC1 has been implicated in multiple human diseases and promotes viral infection, including enhancing SARS-CoV-2 entry. This model supports studies of innate immunity, lectin biology, and pathogen interactions.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Lymphoblast-like, suspension growth
Passage Ratio
1:2~1:4
Cell Line
Raji
Primary Disease
Burkitt's lymphoma
Lineage
B lymphocyte (B cell)
Lineage Subtype
Mature B cell, widely used in EBV-related studies
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
FBS & RPMI
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
SIGLEC1
Full Name
Sialic Acid Binding Ig Like Lectin 1
Alternative Name
CD169; Sialic acid-binding Ig-like lectin 1; SIGLEC1; sialoadhesin; Sialic Acid Binding Ig Like Lectin
Location
20p13
Gene ID
6614
Summary
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and bacterial and viral infections has been shown to enhance SARS-CoV-2 infection.
For Research Use Only.
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