GlycoFlux™ Human STT3B Overexpression Glycoengineered Cell (CAT#: GLJF-0925-JF160)

Description	GlycoFlux™ human STT3B overexpression glycoengineered cell is a stable cell line that constitutively overexpresses STT3B, the catalytic subunit of the oligosaccharyltransferase complex that drives co/post-translational transfer of preassembled N-glycans to Asn sequons. Elevated STT3B increases site occupancy-especially at suboptimal or lumenally exposed sequons-thereby improving folding and secretion of hard-to-glycosylate proteins. This model enables mechanistic studies of N-glycosylation efficiency, rescue of hypoglycosylated CDG variants, and screening of small molecules or sequence designs that modulate occupancy and product quality.
Product Type	Overexpression Cell Lines
Cell Line	As requested by the client.

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	qPCR, Sanger Sequencing
Application	Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	STT3B
Full Name	STT3 oligosaccharyltransferase complex catalytic subunit B
Alternative Name	SIMP; STT3-B; FLJ90106
Location	3p23
Gene ID	201595
Summary	Catalytic subunit of a protein complex that transfers oligosaccharides to asparagine residues; defects cause congenital disorder of glycosylation Ix (CDG1X).