Recombinant Human ARTN Protein, Sia-Increased Human Cell Lines (CAT#: GLJF-0622-JF372)

Product Overview	Recombinant human ARTN protein (NP_001129687.1) is produced in Sia-Increased Human Cell Lines. This expression system is used for the production of glycoproteins with high sialylation and core fucosylation.
Source	Sia-Increased Human Cell Lines
Species	Human
Tag	His-tag, FC-tag
Purity	>90%, determined by SDS-PAGE.
Endotoxin Level	Regular batch
Conjugation	None

Target	ARTN
Full Name	Artemin
Gene ID	9048
Uniprot ID	Q5T4W7
Accession Number	NP_001129687.1
Background	The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternate Names	Enovin; Neublastin; ARTN; EVN