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Recombinant Human FBLN1 protein (NP_001987.2) is produced in Glycoengineered Pichia pastoris. This expression system is used for the production of glycoproteins and antibodies with human post-translational modifications.
Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified.